dtrR [2017-8-11 16:0:3]

D-Tyr resistance regulator (MarR family)

locus: BSU38450

pI: 8.76

mw: 19.50 kDa

protein length: 171 aa

gene length: 513 bp

function: resistance to D-Tyr

product: transcription factor (MarR family)

essential: no

synonyms: ywaE, ipa-10r

Genomic Context

categories

• [category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.2|Transcription factors and their control] → [category|SW 3.4.2.5|Transcription factors/ other]

Gene

Coordinates: 3,946,394 → 3,946,909

The protein

Catalyzed reaction/ biological activity

• repression of the ''[gene|2D4E3D6C3634C3F42A4517D5C1A8F4F48CAFF3A6|dtrR]-[gene|1968743631A20739B5DA8B489CB1E7E42F3B93E3|tyrZ]'' operon [Pubmed|25733610]

Protein family

• [SW|MarR family]

Expression and Regulation

Operons

• genes: [gene|2D4E3D6C3634C3F42A4517D5C1A8F4F48CAFF3A6|dtrR]-[gene|1968743631A20739B5DA8B489CB1E7E42F3B93E3|tyrZ]
  description: [Pubmed|25733610]

  sigma factors

  • [protein|1968743631A20739B5DA8B489CB1E7E42F3B93E3|TyrZ]: sigma factor, [Pubmed|1735721], in [regulon|1968743631A20739B5DA8B489CB1E7E42F3B93E3|TyrZ regulon]

  regulatory mechanism

  • [protein|2D4E3D6C3634C3F42A4517D5C1A8F4F48CAFF3A6|DtrR]: repression, [Pubmed|25733610], in [regulon|2D4E3D6C3634C3F42A4517D5C1A8F4F48CAFF3A6|DtrR regulon]
  • [regulon|T-box|T-box]: anti-termination, in [regulon|T-box|T-box]

  regulation

  • induced by tyrosine limitation ([protein|search|T-box]) [Pubmed|25733610,19258532,1735721]

Biological materials

Mutant

• MGNA-B219 (ywaE::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1218 NBRP B. subtilis, Japan]

References

• 25733610